Basic Information
VIS ID
TVIS44018158
Fusion event
HTLV-1-PODNL1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.12
Reference genome
GRCh37/hg19
Start
14043870/13933057 (Hg38)
End
14043870/13933057 (Hg38)
Orient
+
Location type
Exonic
Fragile sites / regions
FRA19B
Target gene
PODNL1
miRNAs that regulate target gene
hsa-mir-26b-5p
Nearest miRNA
hsa-mir-10395/Upstream/58046; hsa-let-7e/Downstream/140304;
Nearest TSS
ENST00000633603/Upstream/113; ENST00000591802/Downstream/1305;
Nearest CpG islands
chr19-CpG: 53/Target, None/Upstream, None/Downstream
Upstream sequence
GTGGGCAGGCCCATGGGCAGCCGGGTTAGCTGATTCCCTGCCAGGTCGAGGCTGCGCAGGGCACGCAACCGGCGGAAGGCCCGGTGGTGCACACGGGCGC
Downstream sequence
TGGCCAGGCGGTTATAGGCCAGGTTAAGCTCCGTCAGGCCCGGTGTGGCGACCAGGTCACGGGCACCCAGCGCGGCCACGTGGTTGTGGGGCAGCACCAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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