Basic Information
VIS ID
TVIS44018159
Fusion event
HTLV-1-DDX39A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.12
Reference genome
GRCh37/hg19
Start
14526340/14415528 (Hg38)
End
14526340/14415528 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
DDX39A
miRNAs that regulate target gene
hsa-mir-421 ; hsa-mir-378a-3p ; hsa-mir-652-3p ; hsa-mir-99b-5p ; hsa-mir-92a-3p ; hsa-mir-488-3p ; hsa-mir-6730-5p ; hsa-mir-5681a ; hsa-mir-4753-5p ; hsa-mir-6768-3p
Nearest miRNA
hsa-mir-10395/Upstream/342049; hsa-let-7e/Downstream/114015;
Nearest TSS
ENST00000633603/Upstream/2308; ENST00000592794/Downstream/3534;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/8876, chr19-CpG: 67/Downstream/3433
Upstream sequence
tagtagcaggagctacatgcgcccgccaccactaatttttgtatttgtaacagagatggggtttcaccatgttgcccaagctgatctccaacttgtgggc
Downstream sequence
tcaggcgatccgcccacctcagccttccaaagtgctgggattacaggtgtgagccaccacacctggcctcatttctttccatggtcacctaatgttccat
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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