Basic Information
VIS ID
TVIS44018169
Fusion event
HTLV-1-ARMC6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.11
Reference genome
GRCh37/hg19
Start
19163452/19052643 (Hg38)
End
19163452/19052643 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
ARMC6
miRNAs that regulate target gene
hsa-mir-484
Nearest miRNA
hsa-mir-10395/Upstream/666009; hsa-let-7e/Downstream/382420;
Nearest TSS
ENST00000633603/Upstream/18442; ENST00000535478/Downstream/1588;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/18625, chr19-CpG: 59/Downstream/10810
Upstream sequence
ACCATGGCAGTCTCAGCTGGATGTGTACACGCTTGATCATATTCAGCCACAAATCCTTAGGCATATTCATGTGTCTGGCTCCAGGGTGACCATGGTGAGC
Downstream sequence
CAGCCCTGGGAGGTCACAGTGCTGACCGTCAGACCCTAAAGCTTCTGTCTTAACCCCTACCCCCATCCCATCCACTGAACCCACCAGAAAAGTCCTGATT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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