Basic Information
VIS ID
TVIS44018171
Fusion event
HTLV-1-CSNK1G2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
1967144/1967145 (Hg38)
End
1967144/1967145 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
CSNK1G2
miRNAs that regulate target gene
hsa-mir-107 ; hsa-mir-30a-5p ; hsa-mir-155-5p ; hsa-mir-432-5p ; hsa-mir-569 ; hsa-mir-3121-3p ; hsa-mir-6515-5p ; hsa-mir-6825-5p ; hsa-mir-7106-5p ; hsa-mir-4443 ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-7154-3p ; hsa-mir-6503-3p ; hsa-mir-4305 ; hsa-mir-4759 ; hsa-mir-6768-5p ; hsa-mir-1238-3p ; hsa-mir-670-3p ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-7111-3p ; hsa-mir-627-3p ; hsa-mir-877-3p
Nearest miRNA
hsa-mir-1302-11/Upstream/150907; hsa-let-7e/Downstream/266917;
Nearest TSS
ENST00000633603/Upstream/12512; ENST00000591002/Downstream/2681;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/5819, chr19-CpG: 53/Downstream/2294
Upstream sequence
tgtcctttgattagacacaacgctactgcacacttcctagaccacggtatactgtgaacgtaacttgtgtgtgcactgggaaaccagaacattcgagcgg
Downstream sequence
ctGTTGCCGTGCGGAACCCAAGGCCTGTGATCCCCACAGGGTGTTTCTGGCACCGGAACGCAGGGGCCACATCCAGGGGGGCAGTGCTTGTGACGCCGGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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