Basic Information
VIS ID
TVIS44018189
Fusion event
HTLV-1-CD22 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.12
Reference genome
GRCh37/hg19
Start
35824180/35333277 (Hg38)
End
35824180/35333277 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
CD22
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-19a-3p
Nearest miRNA
hsa-mir-10395/Upstream/210513; hsa-let-7e/Downstream/12236;
Nearest TSS
ENST00000633603/Upstream/731; ENST00000613136/Downstream/2776;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/23149, chr19-CpG: 56/Downstream/18250
Upstream sequence
TCTTTCTCACCATGTATTTTTCAGCTTTTGTGACAAACTCGTGTTTGGCCTTAGTACTGGAACCATCCAAGCACCGCATTCCTTTAGTGGGGTGGGTCTG
Downstream sequence
CATGTAACCAGCCTCAGCTCTCCCCCAGGCTGGACCGCCCCCTTCAGACATTGGGGTCTGAAGCTGCATCGCTCACCCCAAACTTAGGGCTGCTCAGAGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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