Basic Information
VIS ID
TVIS44018203
Fusion event
HTLV-1-CHAF1A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
4406455/4406458 (Hg38)
End
4406455/4406458 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
CHAF1A
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-590-3p ; hsa-let-7b-5p ; hsa-mir-92a-3p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-26a-5p ; hsa-mir-26b-5p ; hsa-mir-93-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p
Nearest miRNA
hsa-mir-1227/Upstream/444946; hsa-let-7e/Downstream/39520;
Nearest TSS
ENST00000633603/Upstream/3741; ENST00000587739/Downstream/2987;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/3364, chr19-CpG: 51/Downstream/39556
Upstream sequence
TAAATGCTCCCAAATCCTTCTGCATAAAACGGGGAGTGTGTTCACCCTTGGGCCAGATGAGCGGTTGGATTGTAAtttttttttttttttttttgagacg
Downstream sequence
gagtctcattctgttgcccaggctggagtgcagtggtgcgatctctgctcactgcaacctccgcctcctgggttcaagcaattctcctccttcagcctcc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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