Basic Information
VIS ID
TVIS44018204
Fusion event
HTLV-1-ZNF235 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.31
Reference genome
GRCh37/hg19
Start
44791491/44287338 (Hg38)
End
44791491/44287338 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRA19A
Target gene
ZNF235
miRNAs that regulate target gene
hsa-mir-615-3p
Nearest miRNA
hsa-mir-10395/Upstream/1936133; hsa-let-7e/Downstream/366348;
Nearest TSS
ENST00000633603/Upstream/23025; ENST00000592507/Downstream/3228;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/27179, chr19-CpG: 27/Downstream/17406
Upstream sequence
GACTCTCTGATGGTAGATGAGATGTGACCTCTGACTGAAGCCCTTACAACAGACATCACATATGTAAGGCCTCTCTCCAGTGTGGACTCTCTGGTGTGTG
Downstream sequence
TGAAAATGTGAGGCCTGACTGAAGCCCTTCCCACACTGCTGACACGTATAGGGTTTCTCTCCTGTGTGGACCCTCTGATGGGCACTGAGACCAGCACTCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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