Basic Information
VIS ID
TVIS44018210
Fusion event
HTLV-1-BICRA integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.33
Reference genome
GRCh37/hg19
Start
48130465/47627208 (Hg38)
End
48130465/47627208 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
BICRA
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-200b-5p ; hsa-mir-200a-5p ; hsa-mir-600 ; hsa-mir-3923 ; hsa-mir-3191-3p ; hsa-mir-4725-3p ; hsa-mir-6780b-5p ; hsa-mir-4271 ; hsa-mir-92b-5p ; hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-3202 ; hsa-mir-6818-3p ; hsa-mir-582-5p
Nearest miRNA
hsa-mir-10395/Upstream/400187; hsa-let-7e/Downstream/1382698;
Nearest TSS
ENST00000633603/Upstream/813; ENST00000614245/Downstream/51754;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/16780, chr19-CpG: 122/Downstream/52638
Nearest cancer related gene
BICRA(TSG, No orient, 0)
Upstream sequence
AAGAGCCAGCCTGGGTTGCTGCTGAGCCATTGCAGGCTGAGGCACAGCCTCTCTTTCTCCTTTTACGCTTCCTGATGTCTTCTTTAACATAATCATGGCC
Downstream sequence
ACCTCAGCTTCTTTCAGAGAGCAATATGTTCCTGAGCTAGAGACATGGGTGACCAGCTGGAGTCAGGATTTGGGGGGTGTGGTGTAGGTCTAGAGCCAAC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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