Basic Information
VIS ID
TVIS44018212
Fusion event
HTLV-1-UHRF1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
4939610/4939598 (Hg38)
End
4939610/4939598 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
UHRF1
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-let-7b-5p ; hsa-mir-124-3p ; hsa-mir-146a-5p ; hsa-mir-34a-5p ; hsa-mir-7-5p ; hsa-mir-615-3p ; hsa-mir-191-5p ; hsa-mir-221-3p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-let-7a-5p ; hsa-mir-146b-5p ; hsa-mir-9-5p
Nearest miRNA
hsa-mir-1227/Upstream/6858; hsa-let-7e/Downstream/1450040;
Nearest TSS
ENST00000633603/Upstream/29223; ENST00000588337/Downstream/29515;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/6525, chr19-CpG: 38/Downstream/1911
Nearest cancer related gene
UHRF1(OG, No orient, 0)
Upstream sequence
cctccTTTTCCTTAACACTTAATTTGTTGAGGAATCCTGGTCATTTGTCCCAGGAGTTCCAAATGGCTCTATCCAGACTGTAGAGATGACCAGGAGATGT
Downstream sequence
CACTTGCTGTGTGCGTCTGTGCTACCTGTGAGCTGGTAGGTCAGTGTGTTCCCAcactgtcccatagccaagagccacctgtgctgtgcttgaaatgtgg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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