Basic Information
VIS ID
TVIS44018214
Fusion event
HTLV-1-chr19 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.33
Reference genome
GRCh37/hg19
Start
50835845/50332588 (Hg38)
End
50835845/50332588 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
KCNC3 ; LOC105372437
miRNAs that regulate target gene
hsa-mir-6069 ; hsa-mir-4707-3p ; hsa-mir-7108-3p ; hsa-mir-1226-3p ; hsa-mir-4747-3p ; hsa-mir-4438 ; hsa-mir-4433a-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-6759-3p ; hsa-mir-4448 ; hsa-mir-361-3p ; hsa-mir-4267 ; hsa-mir-6736-3p ; hsa-mir-7108-5p ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-663b ; hsa-mir-7974 ; hsa-mir-874-5p ; hsa-mir-4749-3p ; hsa-mir-637 ; hsa-mir-7110-3p ; hsa-mir-6845-3p ; hsa-mir-136-5p ; hsa-mir-6742-3p ; hsa-mir-939-3p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-6892-3p ; hsa-mir-4793-5p
Nearest miRNA
hsa-mir-10395/Upstream/399451; hsa-let-7e/Downstream/874341;
Nearest TSS
ENST00000633603/Upstream/2866; ENST00000595730/Downstream/927;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/1518, chr19-CpG: 87/Downstream/545
Nearby gene
NAPSB(-1212) ;
Upstream sequence
CATCAGGCCCTGGGAAACTTGGATGCCAGCACTCCCTCATGGCCCTCCACAGACCCCACCAGGGTCTATGGGAGGATTTGTGAGCCTGGAGTCTCCACCC
Downstream sequence
ACCCATTAGAGAGGAGGGGGCTTCTGGAAGCTTCATGAGGGCTCCAAATACTGGACACTCAGCTATGTTCACAGACCAGGAGGAAGTAGACTCGACTCTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate