Basic Information
VIS ID
TVIS44018216
Fusion event
HTLV-1-CTU1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.41
Reference genome
GRCh37/hg19
Start
51604482/51101225 (Hg38)
End
51604482/51101225 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
CTU1
miRNAs that regulate target gene
hsa-mir-7152-5p ; hsa-mir-6818-3p ; hsa-mir-6873-3p ; hsa-mir-4775 ; hsa-mir-593-3p ; hsa-mir-6895-3p ; hsa-mir-6817-3p ; hsa-mir-6870-3p ; hsa-mir-5699-3p ; hsa-mir-4421 ; hsa-mir-6748-3p ; hsa-mir-153-5p ; hsa-mir-1250-3p ; hsa-mir-7110-3p
Nearest miRNA
hsa-mir-10395/Upstream/1168088; hsa-let-7e/Downstream/105704;
Nearest TSS
ENST00000633603/Upstream/16980; ENST00000599948/Downstream/7145;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/2041, chr19-CpG: 88/Downstream/2725
Upstream sequence
tacagacgcagtttctccatgttggccaggctggtcttgaactcctctgagctcaagtgatccacctgcctcggcctcccaaagcggctgggattactag
Downstream sequence
catgtgtcaccacccctgTAATCACTGCAGTGTTTTTGTGTTATCTTTGTTTAGAAGTAACAGTGAGAAATATTTACACACTGGTCACCATGAAATTGAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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