Basic Information
VIS ID
TVIS44018220
Fusion event
HTLV-1-PEG3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.43
Reference genome
GRCh37/hg19
Start
57337499/56826131 (Hg38)
End
57337499/56826131 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
PEG3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-412-3p
Nearest miRNA
hsa-let-7e/Upstream/1437889; hsa-mir-10394/Downstream/1508557;
Nearest TSS
ENST00000633603/Upstream/1125; ENST00000597105/Downstream/9947;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/30467, chr19-CpG: 36/Downstream/12498
Nearest cancer related gene
PEG3(TSG, No orient, 0)
Upstream sequence
CCTCGATCCTGAAGACCTTAGCGACTGGACTATTTCCTTGCTGCCTTCCTTCATAGGACTGAGAAACCACGGAGAGCACAACATAGATAATGCTCTGCTG
Downstream sequence
GGCAGAAGAATCCCAAAGCAAGGGAAGGCAACAGACCAGAGAGTCCAGGCTCCAGATGATTGGTGTGACATTTCAGACATGGTCACTCTAACCCAGGACA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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