VISDB Viral Integration Site DataBase

VIS ID

TVIS44018224

Fusion event

HTLV-1-EVI5L integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Disease

HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)

Quality evaluation

Normal

Reported year

2017

PubMed ID

Virus name

HTLV-1

Reference genome

Not given

Chromosome

chr19

Cytoband

p13.2

Reference genome

Start

End

7914870/7849984 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-34a-5p ; hsa-mir-224-3p ; hsa-mir-34c-5p ; hsa-mir-449a ; hsa-mir-522-3p ; hsa-mir-648 ; hsa-mir-449b-5p ; hsa-mir-1468-3p ; hsa-mir-548f-5p ; hsa-mir-548g-5p ; hsa-mir-548x-5p ; hsa-mir-4302 ; hsa-mir-548aj-5p ; hsa-mir-4698 ; hsa-mir-548aw ; hsa-mir-6499-3p ; hsa-mir-7112-5p ; hsa-mir-135b-3p ; hsa-mir-4278 ; hsa-mir-4280 ; hsa-mir-34b-5p ; hsa-mir-449c-5p ; hsa-mir-2682-5p ; hsa-mir-4514 ; hsa-mir-4692 ; hsa-mir-6734-5p ; hsa-mir-6825-5p ; hsa-mir-766-5p ; hsa-mir-6738-5p ; hsa-mir-5194 ; hsa-mir-1914-3p ; hsa-mir-423-5p ; hsa-mir-3184-5p ; hsa-mir-6089 ; hsa-mir-4459 ; hsa-mir-665 ; hsa-mir-4733-3p ; hsa-mir-4697-5p ; hsa-mir-4488 ; hsa-mir-1237-5p ; hsa-mir-1268b ; hsa-mir-1268a ; hsa-mir-6787-5p ; hsa-mir-663a ; hsa-mir-1908-5p ; hsa-mir-6805-5p ; hsa-mir-6732-5p ; hsa-mir-6794-5p ; hsa-mir-4716-3p

Nearest miRNA

hsa-mir-1227/Upstream/232479; hsa-let-7e/Downstream/539306;

Nearest TSS

Nearest CpG islands

None/Target, chr19-CpG: 112/Upstream/902, chr19-CpG: 216/Downstream/11720

Upstream sequence

AGCCAGGTACCGACATGGACATGGGCCCCTGTACCCCAGGGCCCTGATGAGCAGCGAGATGCCCCTCCCCGCTGCGCTGCCCTGAGCCCCCCCACCTGCC

Downstream sequence

CGTCCCCCCTAGATGCCTGAGGAGGAGGCCTTCTGTGTGTTCGTGCGGCTGATGCAGGAGTACCGGCTGCGGGAGCTCTTCAAACCCAGCATGGCCGAGC