Basic Information
VIS ID
TVIS44018227
Fusion event
HTLV-1-OLFM2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
9982925/9872249 (Hg38)
End
9982925/9872249 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19B
Target gene
OLFM2
Nearest miRNA
hsa-mir-1227/Upstream/1482869; hsa-let-7e/Downstream/166105;
Nearest TSS
ENST00000633603/Upstream/14081; ENST00000592332/Downstream/41587;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/17492, chr19-CpG: 166/Downstream/40910
Upstream sequence
CAGCCTGCTCTTGTCAAACCTTGAGGTATTGGGCAAATATCCCCTGAGTGATAAGCTTGACAGGCCTTAAAGAAGATATCAgccaggcgctgtggctcat
Downstream sequence
gcttgcattcccagcacttcgggaggccaaggcaggcagatggcttgagcttaggagttcgggaccagcctgggcaatatggtaagaccctgtctctacc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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