Basic Information
VIS ID
TVIS44018236
Fusion event
HTLV-1-KAT14 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
p11.23
Reference genome
GRCh37/hg19
Start
18127021/18146377 (Hg38)
End
18127021/18146377 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA20A
Target gene
KAT14
miRNAs that regulate target gene
hsa-mir-26a-5p ; hsa-mir-501-5p ; hsa-mir-1250-3p ; hsa-mir-4793-5p ; hsa-mir-5196-3p
Nearest miRNA
hsa-mir-103a-2/Upstream/7496682; hsa-mir-1-1/Downstream/324238;
Nearest TSS
ENST00000382410/Upstream/1278; ENST00000360010/Downstream/141906;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/8032, chr20-CpG: 67/Downstream/141523
Upstream sequence
tctgtaatcccagcactttgggaggcggaggcggccagatcacctgagctcaggagacaagcctgggcaacgtggtgaaaccccgactctataaaaaaca
Downstream sequence
ggccaggcgcggtggctcatgcctgtaatcccagcactttgggaggctgagggaggcagatcacctgaggtcgggagttcgagaccagcctgaccaacat
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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