Basic Information
VIS ID
TVIS44018253
Fusion event
HTLV-1-RBM39 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
34321628/35733706 (Hg38)
End
34321628/35733706 (Hg38)
Orient
-
Location type
Intronic
Target gene
RBM39
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-484 ; hsa-mir-221-3p ; hsa-mir-26a-5p ; hsa-mir-22-3p ; hsa-mir-369-5p ; hsa-mir-382-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/279609; hsa-mir-1-1/Downstream/2782857;
Nearest TSS
ENST00000382410/Upstream/900; ENST00000617560/Downstream/2935;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/33927, chr20-CpG: 81/Downstream/7862
Upstream sequence
caaaaaaaaagaaaaagaaaaagaaCTAACGCATTAAAATACAATTTGACATTCCTAGACTTTAATGTGACCATTTCAAATACTTCCTAAAGTTACAATG
Downstream sequence
AATACACCAGAAAATGGAGTATGCCATTTTTAAGCCAGTTTATAGAAACCTGTGGGATGCAATCAAAACCAATGATCAACTTGACCTTCACAGACCTTTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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