Basic Information
VIS ID
TVIS44018257
Fusion event
HTLV-1-MROH8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
35771910/37143507 (Hg38)
End
35771910/37143507 (Hg38)
Orient
+
Location type
Intronic
Target gene
MROH8
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-222-3p
Nearest miRNA
hsa-mir-103a-2/Upstream/1689410; hsa-mir-1-1/Downstream/1373056;
Nearest TSS
ENST00000382410/Upstream/34843; ENST00000462163/Downstream/15397;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/47266, chr20-CpG: 70/Downstream/35499
Upstream sequence
AGAGCTGGTATGAAGTGAAGTCCAGGGATACTGGCCTCAATGGCAGGTTGACCTTAACCCCCAAACTAAGAAGGCAAGGCATATATGGGCCAGGAACATG
Downstream sequence
GTGCCTTGTCTCCAAACTACGGAACGTTTAGAGACCACGTTTCCTGGGCAATTgtgtatggttttgttttataagaaactaccagaactttttccaaagt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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