Basic Information
VIS ID
TVIS44018261
Fusion event
HTLV-1-TOX2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q13.12
Reference genome
GRCh37/hg19
Start
42645980/44017340 (Hg38)
End
42645980/44017340 (Hg38)
Orient
-
Location type
Intronic
Target gene
TOX2
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/2848262; hsa-mir-1-1/Downstream/390780;
Nearest TSS
ENST00000382410/Upstream/71635; ENST00000435864/Downstream/21664;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/100843, chr20-CpG: 79/Downstream/98342
Upstream sequence
cttcctgcaccCGCCTGGCTGAGTATGAGTATGGGGTGAATCTTTGTTGTCCGCTGAGTAGGGACCTAAGCTGTGGACGATTGAAAGATGCTCTGGGGTG
Downstream sequence
CTCACCGTCTAGGAGTGGCGGGCAGGGAACAGTGGCCGTGATTTCAGCTTGGTGTCAACCCGGCTTTCCCTGGGGCTGTTATTTCGGCTTCACCACCTCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate