Basic Information
VIS ID
TVIS44018282
Fusion event
HTLV-1-TRMT6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
5926940/5946294 (Hg38)
End
5926940/5946294 (Hg38)
Orient
-
Location type
Intronic
Target gene
TRMT6
miRNAs that regulate target gene
hsa-mir-3138 ; hsa-mir-8071 ; hsa-mir-4722-5p ; hsa-mir-1286 ; hsa-mir-873-5p ; hsa-mir-1205 ; hsa-mir-153-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/2028723; hsa-mir-1-1/Downstream/1425314;
Nearest TSS
ENST00000382410/Upstream/30796; ENST00000378883/Downstream/4183;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/34523, chr20-CpG: 60/Downstream/4022
Upstream sequence
gaaccatttaatggtgggctggagccagaatccaggttatctcatggccaaaggcagtacttgcttcactccactgagctgcAGTTCTTAGATTATGAGT
Downstream sequence
TAAGATTTCTTTTGGGATAGCATGGCCTAGCACTTGGGAATTAGGTGGAGGCTGAGATGTTTCTGACTAGTCAGTTGGAGAGCATCTATTTCACGCATCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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