Basic Information
VIS ID
TVIS44018316
Fusion event
HTLV-1-MIR5009 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
28711604/27339285 (Hg38)
End
28711604/27339285 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
MIR5009
Nearest miRNA
hsa-let-7c/Upstream/385242; hsa-mir-3197/Downstream/3036009;
Nearest TSS
ENST00000624081/Upstream/372772; ENST00000447384/Downstream/21879;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/195298, chr21-CpG: 29/Downstream/1545818
Upstream sequence
acagtgagccgaggtcccacaattgcactccagcctgggcgaccgagcaagactctgtcccGCCCCCACCCCCGAAAAAGATTATCTATTTCCATATCTA
Downstream sequence
ATATCTACCACTTGTCTCTGGCATTGAACAGGGTATTTAGATAAACAAAATCTCATGTTGTTGGAAGAATTTCCTACTTTGCAATTTGCAGTAATCACGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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