Basic Information
VIS ID
TVIS44018319
Fusion event
HTLV-1-HUNK integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q22.11
Reference genome
GRCh37/hg19
Start
33291615/31919303 (Hg38)
End
33291615/31919303 (Hg38)
Orient
+
Location type
Intronic
Target gene
HUNK
miRNAs that regulate target gene
hsa-mir-1229-3p ; hsa-mir-3157-5p ; hsa-mir-6862-3p ; hsa-mir-6784-3p ; hsa-mir-6511b-3p ; hsa-mir-6511a-3p ; hsa-mir-4691-3p ; hsa-mir-3974 ; hsa-mir-1178-3p ; hsa-mir-3907 ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-4719 ; hsa-mir-8485 ; hsa-mir-342-3p ; hsa-mir-377-3p ; hsa-mir-3151-3p
Nearest miRNA
hsa-let-7c/Upstream/1543925; hsa-mir-3197/Downstream/1631359;
Nearest TSS
ENST00000624081/Upstream/45988; ENST00000430354/Downstream/5249;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/45007, chr21-CpG: 63/Downstream/359294
Upstream sequence
AGGAGGAGGGGCTGGAATGAGTGGTATGAGGATGAGGGGCTGGATGGGGTTTCCAGGGGGTATTTCCCCAGCACCATAGATCACCTCATTGCCTTGTCCT
Downstream sequence
TTCACCTTCAGGAAAGGGAGGAGGATGGGCTAGAGAAAGAGCAAGAAGTGAGAGAGTGGGGAGAAATGCTTGGAAATACTGCATTTGCACAGAAGTTGGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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