VISDB Viral Integration Site DataBase

VIS ID

TVIS44018323

Fusion event

HTLV-1-RUNX1 integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Disease

HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)

Quality evaluation

Normal

Reported year

2017

PubMed ID

Virus name

HTLV-1

Reference genome

Not given

Chromosome

chr21

Cytoband

q22.12

Reference genome

Start

End

36254959/34882662 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-27a-3p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-106a-5p ; hsa-mir-423-5p ; hsa-mir-675-5p ; hsa-mir-8485 ; hsa-mir-221-3p ; hsa-mir-7111-3p ; hsa-mir-4792 ; hsa-mir-6721-5p ; hsa-mir-6860 ; hsa-mir-612 ; hsa-mir-5189-5p ; hsa-mir-3187-5p ; hsa-mir-1285-3p ; hsa-mir-939-3p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-6791-5p ; hsa-mir-4292 ; hsa-mir-4308 ; hsa-mir-4762-5p ; hsa-mir-605-5p ; hsa-mir-551b-5p ; hsa-mir-4417 ; hsa-mir-4467 ; hsa-mir-6853-5p ; hsa-mir-8072 ; hsa-mir-4530 ; hsa-mir-3960 ; hsa-mir-922 ; hsa-mir-4789-3p ; hsa-mir-335-3p ; hsa-mir-5096 ; hsa-mir-377-3p ; hsa-mir-6885-3p ; hsa-mir-4446-5p ; hsa-mir-7152-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-3180-5p ; hsa-mir-4639-5p ; hsa-mir-4497 ; hsa-mir-642a-5p ; hsa-mir-513a-5p ; hsa-mir-3160-5p ; hsa-mir-1266-3p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-7157-5p ; hsa-mir-4310 ; hsa-mir-141-5p ; hsa-mir-2115-3p ; hsa-mir-1179 ; hsa-mir-27b-3p ; hsa-mir-128-3p ; hsa-mir-216a-3p ; hsa-mir-3681-3p ; hsa-mir-18a-5p ; hsa-mir-215-5p ; hsa-mir-9-5p ; hsa-mir-101-3p ; hsa-mir-144-5p ; hsa-mir-181a-5p ; hsa-mir-378a-3p

Nearest miRNA

hsa-let-7c/Upstream/1331934; hsa-mir-3197/Downstream/838053;

Nearest TSS

Nearest CpG islands

None/Target, chr21-CpG: 261/Upstream/90025, chr21-CpG: 53/Downstream/3993

Nearest cancer related gene

RUNX1(TSG, No orient, 0)

Upstream sequence

TTTAGTTCCCATTATAAGTGTGTTTGTTGCCATTTAATTAAGAGCAGTGATACGACAATTCCCTTTTTGTTTTAAAAAGATATCACGGAAATAAATCTCC

Downstream sequence

CTGATCAGTTATTTGGTTATTGCTACTGTTTTTTTTTTTTTTCTATTCCCGAAAAATGGGCTTGCTTTATTTTGCTCTTTTTAGTCTCTCACAACAAATT