Basic Information
VIS ID
TVIS44018330
Fusion event
HTLV-1-ETS2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
40196848/38824924 (Hg38)
End
40196848/38824924 (Hg38)
Orient
-
Location type
UTR3
Target gene
ETS2
miRNAs that regulate target gene
hsa-mir-199a-3p ; hsa-mir-199a-5p ; hsa-mir-218-5p ; hsa-mir-877-5p ; hsa-mir-149-5p ; hsa-mir-18a-5p ; hsa-mir-196b-5p ; hsa-mir-455-5p ; hsa-mir-548t-3p ; hsa-mir-3646 ; hsa-mir-3662 ; hsa-mir-548aa ; hsa-mir-548ap-3p ; hsa-mir-548as-3p ; hsa-mir-548at-3p ; hsa-mir-548ay-3p ; hsa-mir-587 ; hsa-mir-1468-3p ; hsa-mir-548f-5p ; hsa-mir-548g-5p ; hsa-mir-548x-5p ; hsa-mir-548aj-5p ; hsa-mir-548aw ; hsa-mir-410-3p ; hsa-mir-582-5p ; hsa-mir-944 ; hsa-mir-607 ; hsa-mir-3671 ; hsa-mir-190a-3p ; hsa-mir-205-3p ; hsa-mir-338-5p
Nearest miRNA
hsa-let-7c/Upstream/3104116; hsa-mir-3197/Downstream/622086;
Nearest TSS
ENST00000624081/Upstream/15288; ENST00000416842/Downstream/21323;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/1999, chr21-CpG: 115/Downstream/357914
Nearest cancer related gene
ETS2(OG, No orient, 0)
Upstream sequence
ggttcagcctaaCAGTTATGGAAACTACAGTCCTTATAAACCATTGGCATGGTAATAAACAGATCTTAAGTATAAAAATTTTGTAATTGGGCCTTTACTC
Downstream sequence
TCTCAATAATAAAGTATTTTGTTTATATAAATTCTTTGTGATAGTCCTCGTTCTTCCTCTCCACACCCAGCATGAAGGAGTTGGAGGAAGGATGTTAACC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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