Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene4624403646188141462288244616114846184476461362624615556746187441461919674618204046186124461850794618894146152384461545754614312746144999461549174615644046151614461526474614676746147696461739564617401546190149
Basic Information
VIS ID
TVIS44018337
Fusion event
HTLV-1-LSS integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
47610063/46190149 (Hg38)
End
47610063/46190149 (Hg38)
Orient
-
Location type
UTR3
Target gene
LSS
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-30a-5p ; hsa-mir-125b-5p ; hsa-mir-10b-5p ; hsa-mir-10a-5p
Nearest miRNA
hsa-let-7c/Upstream/711823;
Nearest TSS
ENST00000624081/Upstream/5070; ENST00000418029/Downstream/3221;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/7323, chr21-CpG: 140/Downstream/38128
Upstream sequence
TGGGCATGAGACTGGCGGCAGCCGTAGGGGTGCCCTGGGTATATGCCGGGCTCCCAGGGTGCCATACCTGCCAGCCAGCCCAGGGAGTGGTGATGGGCTG
Downstream sequence
GGTGCTGGCTGTCCCTGCACATAGCAGTGCCCCGCGGCAGTAACTACAACTGCTGCCTGCCCCTCACCCCTGGTTATGCTCGGCCTCCCCTGTGCATTTC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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