Basic Information
VIS ID
TVIS44018348
Fusion event
HTLV-1-ZDHHC8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
20127784/20140261 (Hg38)
End
20127784/20140261 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZDHHC8
miRNAs that regulate target gene
hsa-mir-25-3p ; hsa-mir-4313 ; hsa-mir-769-5p ; hsa-mir-4786-5p ; hsa-mir-6859-3p ; hsa-mir-5685 ; hsa-mir-4690-3p ; hsa-mir-500b-3p ; hsa-mir-6773-5p ; hsa-mir-6724-5p ; hsa-mir-296-5p ; hsa-mir-3189-5p ; hsa-mir-4758-3p ; hsa-mir-5699-5p ; hsa-mir-324-3p ; hsa-mir-1913 ; hsa-mir-1304-3p ; hsa-mir-6890-3p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929
Nearest miRNA
hsa-mir-1306/Upstream/25510; hsa-let-7a-3/Downstream/108873;
Nearest TSS
ENST00000624155/Upstream/324; ENST00000472497/Downstream/144;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/8150, chr22-CpG: 72/Downstream/2612
Upstream sequence
GCCTCACTGGCTTCCATGTGGTGCTGGTCACTCGGGGGCGCACCACCAACGAGCAGGTGCAGACCCCATGGGGGATGGGTGGCCCCAAAGGGCCGAGAGA
Downstream sequence
GTTGGGGCTGCATGGGGACAGGGTGGGGGCTGGGGCACCCTTGCCTGAGGTAGCTTGTGCAGCTGTGTTGAGACGAGGCTCCAACTCTGAGACCCCCACG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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