Basic Information
VIS ID
TVIS44018355
Fusion event
HTLV-1-KIAA1671 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
25418068/25022101 (Hg38)
End
25418068/25022101 (Hg38)
Orient
-
Location type
Intronic
Target gene
KIAA1671
miRNAs that regulate target gene
hsa-mir-1254 ; hsa-mir-1226-3p ; hsa-mir-940 ; hsa-mir-92b-5p ; hsa-mir-93-3p ; hsa-mir-590-5p ; hsa-mir-551b-3p ; hsa-mir-503-5p ; hsa-mir-423-3p ; hsa-mir-326 ; hsa-mir-192-5p ; hsa-mir-29b-3p ; hsa-mir-92a-3p ; hsa-mir-30a-3p ; hsa-mir-4252 ; hsa-mir-766-3p ; hsa-mir-4267 ; hsa-mir-6777-3p ; hsa-mir-508-5p ; hsa-mir-574-5p ; hsa-mir-1277-5p ; hsa-mir-6818-3p ; hsa-mir-190a-3p ; hsa-mir-6867-5p ; hsa-mir-4711-3p ; hsa-mir-223-5p ; hsa-mir-6895-3p ; hsa-mir-593-3p ; hsa-mir-5011-5p ; hsa-mir-335-3p ; hsa-mir-376a-3p ; hsa-mir-376b-3p ; hsa-mir-500a-3p ; hsa-mir-767-5p
Nearest miRNA
hsa-mir-1286/Upstream/2135722; hsa-let-7a-3/Downstream/433545;
Nearest TSS
ENST00000624155/Upstream/7029; ENST00000461374/Downstream/2551;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/68324, chr22-CpG: 20/Downstream/5905
Nearby gene
KIAA1671(+5873) ;
Upstream sequence
ctgacctcgtgatctgctcgcctcagcctcccaaagtgctgggattacaggcctgagccaccgtgcctggccCCGTTCCTGGCTCTTTGCATGGCTCACT
Downstream sequence
GCACAGGATGGATTTGCAGATTTGGGGACTAAGGTCACATTCCGGAAGATGCTGGAAGGTGTCAGGACCAGCCCACGCCCCTCACCAGATGGTGGCATTC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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