VISDB Viral Integration Site DataBase

VIS ID

TVIS44018356

Fusion event

HTLV-1-GRK3 integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Disease

HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)

Quality evaluation

Normal

Reported year

2017

PubMed ID

Virus name

HTLV-1

Reference genome

Not given

Chromosome

chr22

Cytoband

q12.1

Reference genome

Start

End

25990890/25594923 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-192-5p ; hsa-mir-615-3p ; hsa-mir-339-5p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106a-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-7850-5p ; hsa-mir-19b-2-5p ; hsa-mir-19b-1-5p ; hsa-mir-19a-5p ; hsa-mir-2052 ; hsa-mir-609 ; hsa-mir-6747-5p ; hsa-mir-602 ; hsa-mir-8485 ; hsa-mir-574-5p ; hsa-mir-4455 ; hsa-mir-1305 ; hsa-mir-421 ; hsa-mir-505-3p ; hsa-mir-7159-5p ; hsa-mir-6867-5p ; hsa-mir-620 ; hsa-mir-1270 ; hsa-mir-4531 ; hsa-mir-4683 ; hsa-mir-4709-5p ; hsa-mir-1303 ; hsa-mir-6794-3p ; hsa-mir-411-5p ; hsa-mir-6832-5p ; hsa-mir-193b-5p ; hsa-mir-6728-3p ; hsa-mir-4639-3p ; hsa-mir-483-5p ; hsa-mir-122-5p ; hsa-mir-6836-3p ; hsa-mir-5001-3p ; hsa-mir-4279 ; hsa-mir-1206 ; hsa-mir-3194-3p ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-6778-3p ; hsa-mir-2276-3p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-1304-3p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-4532 ; hsa-mir-1247-3p ; hsa-mir-6890-3p ; hsa-mir-6796-3p ; hsa-mir-527 ; hsa-mir-518a-5p ; hsa-mir-185-3p ; hsa-mir-6829-5p ; hsa-mir-8064 ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p

Nearest miRNA

hsa-mir-1286/Upstream/139212; hsa-let-7a-3/Downstream/960289;

Nearest TSS

Nearest CpG islands

None/Target, chr22-CpG: 279/Upstream/29522, chr22-CpG: 68/Downstream/574545

Nearest cancer related gene

GRK3(OG, No orient, 0)

Upstream sequence

agctgagatcgcgccactgcactccagcctgggcaacagagcgaaactccatctcaaaaataaataaataaataaaataaataaataaaaacaaaaccat

Downstream sequence

atgatcatctcaatagacgtggaaaaagctttcaataaaatccagtacgcttcatgttaaaaatcctgaacaaactagatattgaagggacatacctcaa