Basic Information
VIS ID
TVIS44018357
Fusion event
HTLV-1-MYO18B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
26219356/25823389 (Hg38)
End
26219356/25823389 (Hg38)
Orient
+
Location type
Intronic
Target gene
MYO18B
Nearest miRNA
hsa-mir-1286/Upstream/367678; hsa-let-7a-3/Downstream/731823;
Nearest TSS
ENST00000624155/Upstream/53362; ENST00000534908/Downstream/72206;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/257988, chr22-CpG: 68/Downstream/346079
Nearest cancer related gene
MYO18B(TSG, No orient, 0)
Upstream sequence
TGGCGAGGAAGTCGGATAAGCAAGTCTCTTGGGAAATCCGACTCCTCCAGGGCCATTGCCTAGGGGCCCAGGCCTGGGCAGTTGTCCAAGCTCCCGGCTG
Downstream sequence
AGGAGGCTGGCCTGGAGATTGGGAGGGTGCTGAGATTCTCCGAGGTCCTCTCGGGTGTTCATTCACCCCATGCCCAAGGCCTCACTGCCACGCCTCTGTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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