Basic Information
VIS ID
TVIS44018361
Fusion event
HTLV-1-OSBP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
31204967/30808980 (Hg38)
End
31204967/30808980 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA22B
Target gene
OSBP2
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-122-5p ; hsa-mir-1277-5p ; hsa-mir-190a-3p ; hsa-mir-1285-5p ; hsa-mir-5011-5p ; hsa-mir-410-3p ; hsa-mir-4423-3p
Nearest miRNA
hsa-mir-1286/Upstream/77339; hsa-let-7a-3/Downstream/351082;
Nearest TSS
ENST00000624155/Upstream/5894; ENST00000454145/Downstream/13536;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/5934, chr22-CpG: 84/Downstream/13259
Upstream sequence
aaggtggaggctgcagtgagctgagattgtgccactgcactccagcctgggtgacagagcgagactccgtctcaaaaaaaaaaatgtggacttagacaca
Downstream sequence
cacacagaggagaccaccaggtgaagacacagacagagaggggaaggtcatgtgaagtcagaggcagagattggaattatgctgccacggccaaggaaca
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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