Basic Information
VIS ID
TVIS44018362
Fusion event
HTLV-1-MORC2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
31347646/30951660 (Hg38)
End
31347646/30951660 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA22B
Target gene
MORC2
miRNAs that regulate target gene
hsa-mir-615-3p ; hsa-mir-125a-5p ; hsa-mir-218-5p ; hsa-mir-6515-3p ; hsa-mir-877-3p ; hsa-mir-4692 ; hsa-mir-4514 ; hsa-mir-6715b-5p ; hsa-mir-4269 ; hsa-mir-4742-5p ; hsa-mir-3675-5p
Nearest miRNA
hsa-mir-1286/Upstream/220019; hsa-let-7a-3/Downstream/208402;
Nearest TSS
ENST00000624155/Upstream/9409; ENST00000422839/Downstream/7224;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/29158, chr22-CpG: 100/Downstream/16918
Upstream sequence
ATAAAGGTAGCATTTCTAAGAGGAAAGAGGTCTGTGTAAGGTATTACAAGGGCAAGCCCAAGGCTGCTCTGCAGCCTGGTCCCTGATGATTTCGGAATCT
Downstream sequence
CCCCCAAGCTTCAGTTAACCAATTTTGTACAACTATCTAAGCTGAGAAATCTGTTTTAAATGCTCTTTGTCCTTTCTTCAGGCTAAAAATTCAAGTGAGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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