Basic Information
VIS ID
TVIS44018366
Fusion event
HTLV-1-SLC5A1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
32469313/32073326 (Hg38)
End
32469313/32073326 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA22B
Target gene
SLC5A1
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-1286/Upstream/451795; hsa-let-7a-3/Downstream/1363256;
Nearest TSS
ENST00000624155/Upstream/14156; ENST00000486394/Downstream/9725;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/29871, chr22-CpG: 52/Downstream/102545
Upstream sequence
tgtgccaccatgcccaacttcattctttcgcatgtggatatccagttctcccagtaccattttttgaagaaatgattgttttcccactgaatggtcttgC
Downstream sequence
ACGTAAGTTTTCACTGAACTTGGTGAAAACAGGCTCTTGCCGATAATGCTGTTAAGGTTTTGTCTTGGAGTTGGGGCCAACACCTAGGAATAGTGCTGCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate