Basic Information
VIS ID
TVIS44018372
Fusion event
HTLV-1-TOM1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
35712963/35316970 (Hg38)
End
35712963/35316970 (Hg38)
Orient
+
Location type
Intronic
Target gene
TOM1
miRNAs that regulate target gene
hsa-mir-126-3p ; hsa-mir-30a-5p ; hsa-mir-222-3p ; hsa-mir-150-5p ; hsa-mir-34a-5p ; hsa-mir-1227-5p ; hsa-mir-7843-3p ; hsa-mir-3151-5p ; hsa-mir-128-2-5p ; hsa-mir-128-1-5p ; hsa-mir-6845-5p ; hsa-mir-6762-5p ; hsa-mir-296-5p ; hsa-mir-874-5p ; hsa-mir-324-5p ; hsa-mir-4786-3p ; hsa-mir-345-3p ; hsa-mir-331-3p ; hsa-mir-6810-3p ; hsa-mir-6801-3p ; hsa-mir-338-3p ; hsa-mir-6729-3p ; hsa-mir-1296-3p ; hsa-mir-214-5p ; hsa-mir-3194-5p ; hsa-mir-6748-3p ; hsa-mir-6849-3p ; hsa-mir-6858-3p
Nearest miRNA
hsa-mir-1286/Upstream/1880301; hsa-let-7a-3/Downstream/18670;
Nearest TSS
ENST00000624155/Upstream/5908; ENST00000497448/Downstream/6370;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/16853, chr22-CpG: 38/Downstream/63999
Upstream sequence
ACTGTGCTGGTACCTTGCATGAATCATCACCTCTCTTTGGGGTAGTTCTGCTGGGTGGCTCGGCATCGGTCCCTTCTGTGGGTGCCTCAGAAGGGTACAG
Downstream sequence
GAGGGCCAGGTGACCTGTTAGTAATGGAGCGTTTGCTTCCTAGGTAAAGAAGCTCTCTGTGAGATTCTAGAGGAACCTGGTTACAGGGGATGCCTCTAGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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