Basic Information
VIS ID
TVIS44018373
Fusion event
HTLV-1-TOM1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
35743495/35347502 (Hg38)
End
35743495/35347502 (Hg38)
Orient
+
Location type
UTR3
Target gene
TOM1
miRNAs that regulate target gene
hsa-mir-126-3p ; hsa-mir-30a-5p ; hsa-mir-222-3p ; hsa-mir-150-5p ; hsa-mir-34a-5p ; hsa-mir-1227-5p ; hsa-mir-7843-3p ; hsa-mir-3151-5p ; hsa-mir-128-2-5p ; hsa-mir-128-1-5p ; hsa-mir-6845-5p ; hsa-mir-6762-5p ; hsa-mir-296-5p ; hsa-mir-874-5p ; hsa-mir-324-5p ; hsa-mir-4786-3p ; hsa-mir-345-3p ; hsa-mir-331-3p ; hsa-mir-6810-3p ; hsa-mir-6801-3p ; hsa-mir-338-3p ; hsa-mir-6729-3p ; hsa-mir-1296-3p ; hsa-mir-214-5p ; hsa-mir-3194-5p ; hsa-mir-6748-3p ; hsa-mir-6849-3p ; hsa-mir-6858-3p
Nearest miRNA
hsa-mir-1286/Upstream/10703; hsa-let-7a-3/Downstream/939345;
Nearest TSS
ENST00000624155/Upstream/3316; ENST00000632196/Downstream/24672;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/47385, chr22-CpG: 38/Downstream/33467
Upstream sequence
TGCGCTGCAGTGGGATCTGGCTGCTCTGCCTCCTTTCCCACCCCAGCTGACCATGAGACTTTGCTGAGAAGTGGAGGCCCCAGGACAggctggctggctg
Downstream sequence
gctggctgCTTGACCCAGTGTGACTCTCCTTCACTGAGTGATACCCTGCTCCGGGCCCATGCCCCAAGGAGCCCTTCAGAGCCCACACTGCCAGTCGAGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate