Basic Information
VIS ID
TVIS44018379
Fusion event
HTLV-1-CACNA1I integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
39971118/39575113 (Hg38)
End
39971118/39575113 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
CACNA1I
miRNAs that regulate target gene
hsa-mir-324-3p
Nearest miRNA
hsa-mir-1286/Upstream/1586260; hsa-let-7a-3/Downstream/1238770;
Nearest TSS
ENST00000624155/Upstream/4360; ENST00000471970/Downstream/67684;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/16450, chr22-CpG: 37/Downstream/74417
Upstream sequence
TGGGACCCTTGTGGAGCCTGCAAGGTGGGGTGGGAAAGGGCCACTCGCCCATATGTCAGCACCGCTCCCTGCCTGGCCTGGGCCGTGGGCATGGGCTGTC
Downstream sequence
AGCTGCAGATGCAGCTGCAAGGCCTCTGGATTCGAAATGTCAGGGGATACATTGTGCTACTTGAATCACGGGgaggtggcgtgtggcaccgtggaaagcg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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