Basic Information
VIS ID
TVIS44018392
Fusion event
HTLV-1-PHF21B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.31
Reference genome
GRCh37/hg19
Start
45334780/44938900 (Hg38)
End
45334780/44938900 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
PHF21B
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-4707-3p ; hsa-mir-7108-3p ; hsa-mir-6764-5p ; hsa-mir-1915-3p ; hsa-mir-6798-5p ; hsa-mir-6794-5p ; hsa-mir-4716-3p ; hsa-mir-4747-3p ; hsa-mir-483-3p ; hsa-mir-4279 ; hsa-mir-6780a-3p ; hsa-mir-7111-3p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-1236-3p ; hsa-mir-6845-3p ; hsa-mir-4469 ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-5193 ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-4267 ; hsa-mir-6888-3p ; hsa-mir-6744-3p ; hsa-mir-4757-5p ; hsa-mir-3120-5p
Nearest miRNA
hsa-mir-1281/Upstream/3015603; hsa-let-7a-3/Downstream/262054;
Nearest TSS
ENST00000624155/Upstream/79239; ENST00000432340/Downstream/30183;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/22305, chr22-CpG: 344/Downstream/68108
Upstream sequence
TGGCACTGAATATGGGGCAGGAAATCTGGATGCGCCATTATGGAAATAAATGCACTCTGGCCTCACTGATGACCAGGAAGGCACTAAGGAAGGACTCGTG
Downstream sequence
TCTCGCTTCTCTGCTATGCATTGATAGCACCTGGACCTGCAGAAAAGCAGGAGCTGGTTGAGGACTGAAAAAGACCAAGGACTTCACAAAACCTCCACCA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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