Basic Information
VIS ID
TVIS44018400
Fusion event
HTLV-1-PLXNB2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.33
Reference genome
GRCh37/hg19
Start
50728513/50290084 (Hg38)
End
50728513/50290084 (Hg38)
Orient
-
Location type
Exonic
Target gene
PLXNB2
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-1-3p ; hsa-mir-615-3p ; hsa-mir-331-3p ; hsa-mir-186-5p ; hsa-mir-222-3p ; hsa-let-7b-5p ; hsa-mir-493-3p
Nearest miRNA
hsa-let-7a-3/Upstream/327145; hsa-mir-12114/Downstream/117358;
Nearest TSS
ENST00000624155/Upstream/523; ENST00000453835/Downstream/11378;
Nearest CpG islands
chr22-CpG: 89/Target, None/Upstream, None/Downstream
Upstream sequence
GTAGGCTTCAAAGGCCTCCCTGCTGTCAGTCCGGTCCAACAGCCGAGTGCTCACGATGATGCCGTTGTCGTGTGGCCCATTGCCTTTGCCCACAAACAGC
Downstream sequence
ACGCGGTCACCACCAGGACCCGTGGAGCTCACCAGCCCCACTGTGGCCACGCCCTCATCATTGCTGGCCACGAAAGACTTCTCCCCGCTGCCGTCCTCGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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