Basic Information
VIS ID
TVIS44018415
Fusion event
HTLV-1-ENOX2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q26.1
Reference genome
GRCh37/hg19
Start
130015850/130881876 (Hg38)
End
130015850/130881876 (Hg38)
Orient
-
Location type
Intronic
Target gene
ENOX2
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-4666a-5p ; hsa-mir-8068 ; hsa-mir-143-5p ; hsa-mir-3944-5p ; hsa-mir-5087 ; hsa-mir-4764-5p ; hsa-mir-657 ; hsa-mir-3665 ; hsa-mir-4722-5p ; hsa-mir-1286 ; hsa-mir-873-5p ; hsa-mir-4748 ; hsa-mir-4464 ; hsa-mir-1265 ; hsa-mir-376c-3p
Nearest miRNA
hsa-let-7f-2/Upstream/9510823; hsa-mir-105-1/Downstream/3287502;
Nearest TSS
ENST00000429181/Upstream/172563; ENST00000423277/Downstream/21316;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/479677, chrX-CpG: 37/Downstream/20897
Upstream sequence
TGCACTAGGAAAAAAAAACTTTTGAACAGAATATTCCAGAATACCTATGCAAAGCAGAAGCAATTTAGCCATCCAGCTTCAGAAACTCATGCTTCGGAAC
Downstream sequence
AGCTCGGAACCTTTAGCTAGCAGAAGAGGAGAAAAACCTCTGGTGGTGCAGCTGCTGAAGGTCTGAATACTGCATGtgagtgctaactgtgtgcaagaca
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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