Basic Information
VIS ID
TVIS44018420
Fusion event
HTLV-1-ATP11C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q27.1
Reference genome
GRCh37/hg19
Start
138996071/139913912 (Hg38)
End
138996071/139913912 (Hg38)
Orient
+
Location type
Intronic
Target gene
ATP11C
miRNAs that regulate target gene
hsa-mir-210-3p ; hsa-mir-9-5p ; hsa-mir-652-3p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-4705 ; hsa-mir-3074-3p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-154-3p ; hsa-mir-487a-3p
Nearest miRNA
hsa-let-7f-2/Upstream/1246119; hsa-mir-105-1/Downstream/10236;
Nearest TSS
ENST00000429181/Upstream/81624; ENST00000417426/Downstream/19158;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/221398, chrX-CpG: 154/Downstream/17791
Nearby gene
MIR505(-10236) ;
Upstream sequence
tgtttggtgatctcttcacacggacgcgagtgaAACAGTACTTCCTAAAATTTGTCAATGTTCCCATCCAAAGTATATAAAATTCAGTTCAAACTCATTA
Downstream sequence
CTATTAAAGGGGAAACTGAAATTTGGGGTAGAATACCGTCAAATGTGCAATCAAGAGATGGAGACCCAAAGAGTAAAACAGATAAAAACCCAACAGAAAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate