Basic Information
VIS ID
TVIS44018431
Fusion event
HTLV-1-GRPR integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
16156632/16138509 (Hg38)
End
16156632/16138509 (Hg38)
Orient
+
Location type
Intronic
Target gene
GRPR
miRNAs that regulate target gene
hsa-mir-17-3p
Nearest miRNA
hsa-mir-3690-1/Upstream/2548163; hsa-let-7f-2/Downstream/488503;
Nearest TSS
ENST00000429181/Upstream/14953; ENST00000400004/Downstream/19320;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/282870, chrX-CpG: 95/Downstream/573293
Upstream sequence
TGGAAGGAAATATATCAAAACATGACATGCAAAACTTACAGATGATTTTTGTTTGTTTTTAGAATTCTCTACTAAGATTTTACAATAAGCTCTTTGTAGT
Downstream sequence
TTGATAATAACTTTTTTGAATGAAAAACGTCCTTCAAAATAGCTAAATGCCTCCTAACCACCTTCCTTGTTGATGCTTTTGCTGACTCAAAGCGACTATT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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