Basic Information
VIS ID
TVIS44018435
Fusion event
HTLV-1-SMS integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
p22.11
Reference genome
GRCh37/hg19
Start
21963383/21945265 (Hg38)
End
21963383/21945265 (Hg38)
Orient
+
Location type
Intronic
Target gene
SMS
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-7-1-3p ; hsa-mir-324-3p ; hsa-mir-149-5p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-3613-3p ; hsa-mir-4282 ; hsa-mir-6876-3p ; hsa-mir-626 ; hsa-mir-6516-5p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-455-3p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-6499-3p ; hsa-mir-2467-3p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-1827 ; hsa-mir-4468 ; hsa-mir-5186 ; hsa-mir-3192-5p ; hsa-mir-4257 ; hsa-mir-4756-3p ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-7851-3p ; hsa-mir-490-3p ; hsa-mir-508-3p ; hsa-mir-1273e ; hsa-mir-219b-3p ; hsa-mir-302f
Nearest miRNA
hsa-mir-23c/Upstream/1928078; hsa-let-7f-2/Downstream/6550290;
Nearest TSS
ENST00000429181/Upstream/4220; ENST00000475778/Downstream/87176;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/3682, chrX-CpG: 25/Downstream/1386902
Upstream sequence
AGACAGCTCTGGTACATGGTAGATATTTGGTACACGCTGATTAAATAGACCAAGTTTATGTTATGGTAAAGGTGGAATGCTGGTTCATGTCCATTAGGGG
Downstream sequence
AAAGTGAGATGCTCATTTACCTTGTAGAATTATGAGGATGGTCCAGAATTCAGAAACGTGGCAGATACTGTTAGGTCTGTCATTTGGACCATTGCTATAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate