Basic Information
VIS ID
TVIS44018436
Fusion event
HTLV-1-PHEX integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
p22.11
Reference genome
GRCh37/hg19
Start
22125335/22107217 (Hg38)
End
22125335/22107217 (Hg38)
Orient
-
Location type
Intronic
Target gene
PHEX
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-4760-5p ; hsa-mir-8061 ; hsa-mir-4709-3p ; hsa-mir-4635 ; hsa-mir-1277-5p ; hsa-mir-190a-3p ; hsa-mir-3935 ; hsa-mir-5011-5p ; hsa-mir-6831-5p ; hsa-mir-3927-3p ; hsa-mir-5580-3p ; hsa-mir-4797-3p ; hsa-mir-545-5p ; hsa-mir-574-3p ; hsa-mir-8485 ; hsa-mir-4719 ; hsa-mir-186-5p ; hsa-mir-155-3p ; hsa-mir-3941 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-590-3p ; hsa-mir-3154 ; hsa-mir-802
Nearest miRNA
hsa-mir-23c/Upstream/2090030; hsa-let-7f-2/Downstream/6388338;
Nearest TSS
ENST00000429181/Upstream/16724; ENST00000323684/Downstream/65766;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/165634, chrX-CpG: 25/Downstream/1224950
Upstream sequence
tgtaaaatgggtataataacatctctcttacagcagcactgtgaggatcataattaatgtgagatgcctaAATGGGATGATCTCAGGGGAGCTGGAAGGG
Downstream sequence
CCCCTGCTTCTCAAACCCCAGTATACTTTGCCATACTACATCTTCCACCACCACCATTGGGCCCCCTAACAACTTCCCTAGTTATTCTGGCTCATCACCA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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