Basic Information
VIS ID
TVIS44018443
Fusion event
HTLV-1-BCOR integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
p11.4
Reference genome
GRCh37/hg19
Start
39962364/40103111 (Hg38)
End
39962364/40103111 (Hg38)
Orient
+
Location type
Intronic
Target gene
BCOR
miRNAs that regulate target gene
hsa-mir-425-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-615-3p ; hsa-mir-598-3p ; hsa-mir-346 ; hsa-mir-328-3p ; hsa-mir-320a ; hsa-mir-191-5p ; hsa-mir-125b-5p ; hsa-let-7f-5p ; hsa-let-7c-5p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-340-5p ; hsa-mir-410-3p ; hsa-mir-335-3p ; hsa-mir-6809-3p ; hsa-mir-4753-3p ; hsa-mir-5007-3p ; hsa-mir-190a-3p ; hsa-mir-3145-3p ; hsa-mir-5197-3p ; hsa-mir-5590-3p ; hsa-mir-142-5p
Nearest miRNA
hsa-mir-1587/Upstream/265498; hsa-let-7f-2/Downstream/5643046;
Nearest TSS
ENST00000429181/Upstream/5708; ENST00000447570/Downstream/43518;
Nearest CpG islands
chrX-CpG: 1095/Target, None/Upstream, None/Downstream
Upstream sequence
TCTGCTCTCGGTGCTCATCCTCCTCTCCATACCTGCGTTCCCAGCGCGTTAGCAGCCGCGCAGCCCCCGGCCCTGAGTGCGGGGGGTGGGGTGGGGGGGC
Downstream sequence
TCAGGGTGGTTTGTGTGGTGCGGCCTGACAGAACCTTCTGTGTGCGGCGGAGGGAGGAGGCTAATGCATAATGCACAGCGCCTGGAAGCCCGGCCATTAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate