Basic Information
VIS ID
TVIS44018453
Fusion event
HTLV-1-STARD8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
67867789/68647947 (Hg38)
End
67867789/68647947 (Hg38)
Orient
+
Location type
Intronic
Target gene
STARD8
miRNAs that regulate target gene
hsa-mir-186-5p ; hsa-mir-125b-5p ; hsa-mir-297 ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-511-3p ; hsa-mir-5011-5p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-1277-5p ; hsa-mir-4718 ; hsa-mir-656-3p ; hsa-mir-4789-3p ; hsa-let-7g-3p ; hsa-let-7a-2-3p ; hsa-mir-3675-3p ; hsa-mir-30e-3p ; hsa-mir-30d-3p ; hsa-mir-30a-3p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-4298 ; hsa-mir-1302 ; hsa-mir-4425 ; hsa-mir-1273g-5p ; hsa-mir-92a-1-5p ; hsa-mir-876-3p ; hsa-mir-323a-5p ; hsa-mir-3649 ; hsa-mir-711 ; hsa-mir-6758-3p ; hsa-mir-205-3p
Nearest miRNA
hsa-let-7f-2/Upstream/2628968; hsa-mir-105-1/Downstream/1374910;
Nearest TSS
ENST00000429181/Upstream/179; ENST00000374597/Downstream/45704;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/148718, chrX-CpG: 41/Downstream/38322
Upstream sequence
GCCCCGCCGGCCCTAGAAGCTCCCCACGCGCCACCATGCCTCTGCTGGACGTTTTCTGGTCTTGCTTCAGGAAGGTGAAGGTAAGTGACTGGCCAGCCCC
Downstream sequence
AGCCCATCCCGCTGCTCAGGGGGGAAGGAGGCAGATGTGGACCACTGCGCACCAGCTGGGAAAACGGACCAGACGGGCTTCTGAGACTACCTGAGGCTct
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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