Basic Information
VIS ID
TVIS44018465
Fusion event
HTLV-1-RPS6KA6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
83442020/84187012 (Hg38)
End
83442020/84187012 (Hg38)
Orient
-
Location type
Intronic
Target gene
RPS6KA6
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-192-3p ; hsa-mir-129-5p ; hsa-mir-2113 ; hsa-mir-4687-3p ; hsa-mir-5010-3p ; hsa-mir-627-3p ; hsa-mir-758-3p ; hsa-mir-7974 ; hsa-mir-889-5p
Nearest miRNA
hsa-let-7f-2/Upstream/5285763; hsa-mir-105-1/Downstream/38740;
Nearest TSS
ENST00000429181/Upstream/871; ENST00000373173/Downstream/886;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/676244, chrX-CpG: 95/Downstream/376
Nearest cancer related gene
RPS6KA6(TSG, No orient, 0)
Upstream sequence
CGCTTTTATAACAACAATAAAAACAAAGCACCTGTGTACATCTAAGTTCTCACTGCACAGCTGACCAAAGCCCAACCAGAACAGTTTCAGAGTAAGAAGA
Downstream sequence
GTGGGAAGAGAGGTGAACCAAAGTATTTTGGTTGAACCTCGCTAAGTCTTACCAAAGATTCGACTTATTTATAAGGGCTGGGGTTTACTTTGCGTCTTCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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