Basic Information
VIS ID
TVIS44018505
Fusion event
HTLV-1-KCNC4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
110757430/110214808 (Hg38)
End
110757430/110214808 (Hg38)
Orient
+
Location type
Intronic
Target gene
KCNC4
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-103a-3p ; hsa-mir-16-5p ; hsa-let-7b-5p ; hsa-mir-369-3p ; hsa-mir-374a-5p ; hsa-mir-374b-5p ; hsa-mir-3924 ; hsa-mir-4517 ; hsa-mir-5583-3p ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-3941 ; hsa-mir-625-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-4801 ; hsa-mir-4731-3p ; hsa-mir-25-3p ; hsa-mir-3176 ; hsa-mir-3179 ; hsa-mir-32-5p ; hsa-mir-3622a-3p ; hsa-mir-3622b-3p ; hsa-mir-363-3p ; hsa-mir-367-3p ; hsa-mir-3922-3p ; hsa-mir-3936 ; hsa-mir-4757-5p ; hsa-mir-6728-3p ; hsa-mir-6744-3p ; hsa-mir-6765-3p ; hsa-mir-6864-5p ; hsa-mir-6878-3p ; hsa-mir-7515 ; hsa-mir-92a-3p ; hsa-mir-92b-3p
Nearest miRNA
hsa-mir-101-1/Upstream/615841; hsa-mir-11399/Downstream/2246962;
Nearest TSS
ENST00000473358/Upstream/2660; ENST00000636402/Downstream/4908;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/2636, chr1-CpG: 31/Downstream/8235
Upstream sequence
cacCTTCTTTCCACTGAACTAGGCTGTTTTTGAGGCAGAGAGCTTGTTTCTTACTGTAGCCTGAGAAATGTCCTTCTGAGGTTCTGTACCTCCTGTGGAT
Downstream sequence
GACATCAGAAAACCCAGGGGCAGATGGAGACGTCAGAAGGAAGACTTACTGTATTACCCCTCCAGGCCTGAGGGTACTATGCCATGCGGGGAGTTCTGGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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