Basic Information
VIS ID
TVIS44018509
Fusion event
HTLV-1-MTOR integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.22
Reference genome
GRCh37/hg19
Start
11324558/11264501 (Hg38)
End
11324558/11264501 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
MTOR
miRNAs that regulate target gene
hsa-mir-99a-5p ; hsa-mir-520c-3p ; hsa-mir-373-3p ; hsa-mir-99b-5p ; hsa-mir-144-3p ; hsa-mir-100-5p ; hsa-mir-199a-3p ; hsa-mir-16-5p ; hsa-mir-744-5p ; hsa-mir-181b-5p ; hsa-mir-101-3p ; hsa-let-7c-5p ; hsa-mir-218-5p ; hsa-mir-496 ; hsa-mir-196b-5p ; hsa-mir-224-5p ; hsa-mir-128-3p ; hsa-mir-193a-5p ; hsa-mir-125a-5p ; hsa-mir-497-5p ; hsa-mir-3188
Nearest miRNA
hsa-mir-12136/Upstream/1297043; hsa-mir-101-1/Downstream/764657;
Nearest TSS
ENST00000473358/Upstream/1994; ENST00000376810/Downstream/8705;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/1522, chr1-CpG: 29/Downstream/8701
Nearby gene
MTOR(-1950) ;
Nearest cancer related gene
MTOR(OG, No orient, 0)
Upstream sequence
ctgcactgcagcctgggcagcagagaaagatcctgtctcaaataataataataacaataaatagtggtaattagatgaatatttgctaagaaggaaaagg
Downstream sequence
ttcacaactAGTTTAAAAATTACAAGTTGTGCAACAATGTAAGTATAATACAACCATTTACAAAAATATTTATGCATTTCTTATATGTCTCTGTTTACAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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