Basic Information
VIS ID
TVIS44018534
Fusion event
HTLV-1-NBPF10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
145610182/145824929 (Hg38)
End
145610182/145824929 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1F
Target gene
NBPF10
miRNAs that regulate target gene
hsa-mir-342-3p ; hsa-mir-216b-3p ; hsa-mir-4798-3p ; hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-30e-3p ; hsa-mir-30d-3p ; hsa-mir-30a-3p ; hsa-mir-3942-3p ; hsa-mir-7154-5p ; hsa-mir-549a ; hsa-mir-1250-3p ; hsa-mir-8060 ; hsa-mir-1324 ; hsa-mir-641 ; hsa-mir-3617-5p ; hsa-mir-1277-5p ; hsa-mir-6516-3p ; hsa-mir-190a-3p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-5011-5p ; hsa-mir-4789-3p ; hsa-mir-362-3p ; hsa-mir-329-3p
Nearest miRNA
hsa-mir-101-1/Upstream/28730201; hsa-mir-1182/Downstream/25658;
Nearest TSS
ENST00000473358/Upstream/546; ENST00000479819/Downstream/11608;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/496, chr1-CpG: 40/Downstream/20603
Upstream sequence
aaaaatgtatgcataggaaaagactatgcatcaaatttatctctatgggattatgcgtgattctgattttccttAAAGATTGGGAGATGATTTTGCGGTC
Downstream sequence
TGTCACAGACCTTAGTTTCTACACTTCCCTGCTTGGAAGAATTAAGGTCACTGTTCACAGCTCGGTGGGAGTGAACAGGCAGTGTTATTCTCAGTCCATA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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