Basic Information
VIS ID
TVIS44018536
Fusion event
HTLV-1-ACP6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
147104455/147632659 (Hg38)
End
147104455/147632659 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1F
Target gene
ACP6
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-744-3p ; hsa-mir-8057 ; hsa-mir-106a-3p ; hsa-mir-4423-5p ; hsa-mir-6501-5p ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-564 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-183-5p ; hsa-mir-454-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-130a-3p ; hsa-mir-5197-5p
Nearest miRNA
hsa-mir-101-1/Upstream/1782014; hsa-mir-1182/Downstream/701820;
Nearest TSS
ENST00000473358/Upstream/21046; ENST00000431525/Downstream/18023;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/32508, chr1-CpG: 80/Downstream/37061
Nearby gene
BCL9(+6435) ;
Upstream sequence
AATGACAGCGAAGGGAACAGCTTAAACAAAATTGATCATGTGCACAATAGAATGTGAAATTGAAAAGGGAGGGAAGAATGAATAGCCCCAAAAGCCAAGA
Downstream sequence
AAAGGAATTTCATCTTGATATGGGAAACAATTGGGACCCACTCTTTGGTCTTAATCAGAGGACTTACATGCTAAGTGTTTTATCAAGTGAGTCTGGCAGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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