Basic Information
VIS ID
TVIS44018539
Fusion event
HTLV-1-CELF3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
151687493/151715017 (Hg38)
End
151687493/151715017 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1F
Target gene
CELF3
miRNAs that regulate target gene
hsa-mir-4640-5p ; hsa-mir-4726-5p ; hsa-mir-4755-3p ; hsa-mir-885-3p
Nearest miRNA
hsa-mir-101-1/Upstream/169126; hsa-mir-1182/Downstream/1974688;
Nearest TSS
ENST00000473358/Upstream/4584; ENST00000451222/Downstream/967;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/102288, chr1-CpG: 25/Downstream/6498
Upstream sequence
GGCTTTGTGTAGGGAGAGAAGGACCATGTGACCGCCAGACAAGTAAGAGTAGTGTGGCTTTCTCTCCTGCTGAGCTGTtctcctttcccctctctccctc
Downstream sequence
acctccacctccctccatcttgatcaccatcatccctctcttctcccattttccctatttcctcatctctccccacctccACCATAGGCAGGTGGAGGAC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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