Basic Information
VIS ID
TVIS44018550
Fusion event
HTLV-1-CD5L integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
157804824/157835034 (Hg38)
End
157804824/157835034 (Hg38)
Orient
-
Location type
Intronic
Target gene
CD5L
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-101-1/Upstream/898790; hsa-mir-1182/Downstream/2064945;
Nearest TSS
ENST00000473358/Upstream/14929; ENST00000359209/Downstream/6764;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/639689, chr1-CpG: 28/Downstream/143896
Upstream sequence
CAAATTCAAAGCTGAATCATTATcatttctgtagcattttaatttttcaaattgttttcatgttcaacttgtcatttgatcctcacaagagatcttgtAT
Downstream sequence
AGACTTTTAAAAATAAATACAATAACATACAAGATATATCCAACACCAAATGCTTTTTGGTTCATTGTTGGCGTTATGAACTAAATATCTCAGATTAGTG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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